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KMID : 1039420190530030192
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 3 p.192 ~ p.197
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Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
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Kang Myung-Hee
Kim Na-Rae
Chung Dong-Hae
Yie Gie-Taek
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Abstract
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A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
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KEYWORD
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Solitary fibrous tumors, Hemangiopericytoma, Frozen, Cytology, Central nervous system
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